If you are taking tadalafil to treat erectile dysfunction, you should know that it does not cure erectile dysfunction or increase sexual desire. Tadalafil does not prevent pregnancy or the spread of sexually transmitted diseases such as human immunodeficiency virus (HIV).

The half-life of tadalafil is approximately 17.5 hours.
This long half-life is what allows for the 36-hour window of effectiveness.
It is primarily metabolized by the liver enzyme CYP3A4.
Drugs that inhibit CYP3A4 can increase tadalafil concentrations in the blood.
Your doctor will adjust the dose if you are on such interacting medications.
Understanding pharmacokinetics helps explain dosing instructions.

It may be taken with or without food. If you are taking tadalafil to treat erectile dysfunction, follow your doctor's directions and the guidelines in this paragraph.

Step	Description	Tips
Dose Timing	Take 30 mins to 1 hour before activity	Avoid heavy meals immediately before
Administration Method	Swallow whole with water	Do not crush or chew
Alcohol Consideration	Limit alcohol intake to reduce side effects	Excessive alcohol may impair effectiveness

There are two different ways to take tadalafil, either daily or on an as needed basis. Talk to your doctor about which dosing schedule is right for you. Tadalafil is sometimes taken as needed, usually at least 30 minutes before sexual activity and not more often than once every 24 hours.

What should I know about storage and disposal of this medication?

Tadalafil (Adcirca) is used to improve the ability to exercise in people with pulmonary arterial hypertension (PAH; high blood pressure in the vessels carrying blood to the lungs, causing shortness of breath, dizziness, and tiredness). Tadalafil is in a class of medications called phosphodiesterase (PDE) inhibitors. It works to treat erectile dysfunction by increasing blood flow to the penis during sexual stimulation. This increased blood flow can cause an erection. Tadalafil treats PAH by relaxing the blood vessels in the lungs to allow blood to flow more easily. Your doctor will help you decide the best time for you to take tadalafil before sexual activity.

Condition	Caution	Alternative Actions
Nitrate medication use	Dangerous interactions, avoid combining	Consult doctor
Severe liver impairment	May require dose adjustment	Medical supervision
Recent stroke or heart attack	Increased risk, should consult healthcare provider	Avoid use until cleared

Tadalafil is also sometimes taken once a day every day without regard to timing of sexual activity. You may attempt sexual activity at any time between doses.

Product	Dosage	Quantity + Bonus	Price
Cialis Super Active	20mg	20 + 4 Pills	92.35€ 87.95€
Cialis Generic	20mg	10 Pills	31.49€ 29.99€
Cialis Generic	20mg	120 + 8 Pills	188.15€ 179.19€
Cialis Original	20mg	4 Pills	41.99€ 39.99€
Cialis Generic	10mg	10 Pills	31.41€ 29.91€
Cialis Professional	20mg	360 + 6 Pills	807.03€ 768.60€
Cialis Generic	40mg	10 Pills	37.79€ 35.99€
Cialis Soft Tabs	20mg	90 + 6 Pills	216.71€ 206.39€
Cialis Super Active	20mg	270 + 30 Pills	661.49€ 629.99€
Cialis Generic	20mg	180 + 10 Pills	254.09€ 241.99€
Cialis Super Active	20mg	90 + 10 Pills	314.14€ 299.18€
Cialis Generic	2.5mg	180 + 10 Pills	154.86€ 147.49€

If you are taking tadalafil on a regular schedule, take it at around the same time every day.

Other uses for this medicine

Find the clinically proven ED treatment that suits you best. No names, no logos, no delivery fee. 4.6* from over 33,000 people like you. BSc (Hons) MBBS MRCGP AFHEA MA (Hons) AFMCP Answer a few simple questions to get the treatment you need. Tadalafil (Cialis) is used to treat erectile dysfunction (ED, impotence; inability to get or keep an erection), and the symptoms of benign prostatic hyperplasia (BPH; an enlarged prostate) which include difficulty urinating (hesitation, dribbling, weak stream, and incomplete bladder emptying), painful urination, and urinary frequency and urgency in adult men. If you have certain health conditions or are taking certain medications, your doctor may tell you to take tadalafil less often or may prescribe a lower dose to be taken once a day. Follow the directions on your prescription label carefully, and best price for cialis 5 mg ask your doctor or pharmacist to explain any part you do not understand.

Common Side Effects	Less Common Side Effects	Severe Reactions	Action to Take
Headache	Dizziness	Priapism (prolonged erection)	Seek immediate medical help
Flushing	Nasal congestion	Vision changes	Discontinue use, consult doctor
Indigestion	Muscle pain	Sudden hearing loss	Seek urgent medical attention

Do not take more or less of it or take it more often than prescribed by your doctor.

Cialis prices

Try different timing if you take it as needed: You may need to take Cialis a few times for you to figure out the best timing for as-needed dosing. Don’t take more than one dose in a day. Be consistent for daily use: Some people prefer the daily dose because it allows small amounts of Cialis to always be in your bloodstream, so you can have flexibility with sexual activity. For the daily dose, try to take it at the same time every day. Cialis can last up to 36 hours in the body, but may last up to 72 hours in some cases.

Your expert team

Your age, genetics, and whether you have heart, liver, or kidney disease all affect how the drug works and how long Cialis stays in your body. You may need dose adjustments to avoid side effects. The dosage of Cialis and how it’s prescribed for you depend on: other conditions you may have, such as diabetes or high blood pressure If you have heart, kidney, or liver disease, it’s important to discuss your ED treatment options with a doctor. You may need a lower dose of Cialis to avoid side effects. Do not take Cialis with nitrate class angina medications or alpha blocker medications.

2. They Have Different Price Points

They can cause a dangerous drop in your blood pressure. Avoid excess alcohol because it can cause low blood pressure, dizziness, and fainting. Avoid grapefruit juice with Cialis, as it interacts with the medication. Take the medication as prescribed by your doctor. Ask a pharmacist about interactions with other medications. If you are taking tadalafil to treat PAH or BPH, follow your doctor's directions and the guidelines in this paragraph.

Available Forms and Strengths

Addressing signs of trouble early could help treat ED or may lead to an early diagnosis of a condition like cardiovascular disease or diabetes — two common causes of ED, especially in younger people. While you may experience no side effects or complications from taking 40 mg of Cialis, you do run the risk of problems like a sudden drop in blood pressure, which can, in turn, lead to fainting and a possible injury from a fall. Taking too much Cialis also means any side effects you experience, such as headaches, priapism, and leg or back pain, are more likely to last longer than side effects accompanying a standard dose. Cialis is a prescription medication, and you should take only the prescribed amount. The dose may be 10 or 20 mg for occasional use before sexual activity or 2.5 or 5 mg for ongoing daily use.

Alternatives for ED and BPH

If you find that the prescribed dose isn’t effective or is causing unwanted side effects, speak with your doctor about changing the dose or trying a different type of ED treatment. Like any medication, tadalafil can be problematic or even dangerous if you take too much. The medication is designed to significantly impact your circulation, so taking too much may cause severe reactions that negatively affect your sexual health and blood flow throughout the body. If the Cialis dose your doctor prescribed doesn’t seem to be helping, don’t double your dose to 40 mg on your own. This could increase purchase cialis professional the risks of serious adverse reactions or side effects.

Overdose symptoms

Make an appointment to speak with a doctor about possible causes and alternative treatment options, including other PDE5 inhibitors, medications, and lifestyle changes that might help. It’s important to discuss your sexual history, medications you’re taking, and your overall health and concerns about ED with a doctor. All content on this page has been medically reviewed by: Hassan Thwaini, Clinical Pharmacist and Copywriter, Master of Pharmacy (MPharm) on 30 March, 2026. Tadalafil is a clinically-proven erectile dysfunction treatment that gives you the freedom to enjoy sex when you want it. It lasts for 36 hours - so there’s less need for planning before sex. You should take tadalafil one time a day. Take all of the tablets for your daily dose at one time each day; do not divide the tablets to take as separate doses.

Cialis 20 mg helps achieve and maintain an erection.
A 30-pill pack provides convenience and discreetness.
Consult your doctor about possible drug interactions.
Avoid grapefruit juice while taking Cialis.
Cialis 20 mg can improve confidence in intimacy.
The medication should be stored out of children’s reach.

Take tadalafil at around the same time every day. If you are already taking medication to treat BPH, your doctor may tell you to stop taking your other medication at least one day before starting treatment with tadalafil. Follow your doctor's directions carefully, and ask your doctor or pharmacist to explain any part you do not understand. If you are taking tadalafil for erectile dysfunction, your doctor will probably start you on an average dose of tadalafil and increase or decrease your dose depending on your response to the medication.

Cialis 20 mg is effective for both occasional and regular use.
The medication may cause a mild headache initially.
Take Cialis 20 mg consistently if prescribed daily.
Avoid activities that require alertness after taking.
Follow your doctor’s guidance for safety.
Keep Cialis 20 mg out of direct sunlight.

Tell your doctor if tadalafil is not working well or if you are experiencing side effects.

World Federation of Neurology

Increase your physical activity and eat a healthy diet. Communicate with your partner about your concerns. Increasing your dose of Cialis increases your chances of serious side effects and damage, including: low blood pressure (a higher dose may increase the risk of dizziness and fainting) priapism (a higher dose may increase this risk due to the longer effect of Cialis) sudden change or loss of vision or hearing Call your doctor if you feel you’re experiencing serious side effects. Get medical help right away if you experience an erection lasting longer than 4 hours. Some common side effects of Cialis include: muscle pain and back pain (higher doses may increase the risk of these effects) If you feel you’re experiencing these symptoms of a serious allergic reaction to Cialis, seek immediate medical attention or call 911 or your local emergency medical services: Cialis is one of the most popular ED medications sold worldwide.

Alternatives for benign prostatic hyperplasia (BPH)

It’s also very common to find Cialis and other ED medications sold online without a prescription through fake pharmacies and other suspect online portals. Buying prescription medications online through fake sites can jeopardize your health, but may also compromise your data and privacy. Fake products are designed to look exactly like the genuine prescription but may be contaminated, have more or less than the listed strength or dose, be expired, have harmful ingredients, and harm your health. You can’t tell what’s in these products just by looking. The is cialis a daily pill best way to learn more about ED is to make an appointment with a doctor.

It’s in your system for a while and clears slowly

They can diagnose the cause of your ED and offer a prescription, if needed. Telehealth options (sometimes covered by insurance, including Medicare plans), such as over-the-phone, online services, and telemedicine apps, can connect you with a doctor. Occasional episodes of ED are typical and could be due to causes such as work stress, relationship troubles, or excessive alcohol consumption. But if you are experiencing ED at least 25% of the time, you should speak with a doctor. You should also discuss any minor changes in your erections or libido. If you are taking tadalafil for PAH, you should know that tadalafil controls PAH but does not cure it. Continue to take tadalafil even if you feel well. Do not stop taking tadalafil without talking to your doctor. Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information. tell your doctor and pharmacist if you are allergic to tadalafil, any other medications, or any of the ingredients in tadalafil tablets. Ask your pharmacist for a list of the ingredients.

Cialis 20 mg offers a long-lasting effect for intimacy.
The 30-pill bottle provides a one-month supply.
Always follow your healthcare provider’s instructions.
Cialis 20 mg can interact with alcohol.
Discontinue use if you experience chest pain.
Cialis 20 mg is not suitable for women.

tell your doctor if you are taking or have recently taken riociguat (Adempas) or nitrates such as isosorbide dinitrate (Isordil), isosorbide mononitrate (Monoket), and nitroglycerin (Minitran, Nitro-Dur, Nitromist, Nitrostat, others).