Calculate the required quantity of each ingredient for the total amount to be prepared.
What is Sildenafil Citrate Oral Jelly?
It is recommended to apply the gel as directed, typically before sexual activity, to allow sufficient time for the medication to take effect. Patients should be aware of potential side effects, such as local irritation or allergic reactions, and report any adverse effects to their healthcare provider. If you have any questions about this formulation or its use, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the information and support you need to make informed decisions about your health and treatment options. Sildenafil Citrate 10 mg/g Vaginal Gel, while primarily formulated for specific gynecological purposes, may have other potential uses that could be of interest to both patients and prescribers.
Q. When should I take it?
This gel-like semisolid formulation is designed for easy and controlled application in the vaginal area, which allows for localized delivery of medication. Beyond its primary indications, this formulation may be explored for its potential benefits in enhancing sexual function by increasing blood flow to the vaginal tissues, which could improve lubrication and sensitivity, potentially benefiting individuals experiencing sexual dysfunction or discomfort during intercourse. Additionally, the vasodilatory effects of Sildenafil Citrate might be investigated for their potential to alleviate symptoms associated with sildenafil 50 mg india certain pelvic conditions, such as pelvic congestion syndrome, where increased blood flow could help reduce discomfort. The gel formulation also offers a unique advantage in providing a soothing and lubricating effect, which may be beneficial for individuals experiencing vaginal dryness or irritation, whether due to hormonal changes, menopause, or other factors. This could improve overall vaginal health and comfort, making it a versatile option for those seeking relief from such symptoms.
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Furthermore, the localized application minimizes systemic absorption, potentially reducing the risk of systemic side effects commonly associated with oral administration of Sildenafil. This makes it a potentially safer alternative for individuals who may be sensitive to systemic effects or who are taking other medications that could interact with oral Sildenafil. As with any medication, it is important for patients and prescribers to discuss the potential benefits and risks, considering individual health conditions and treatment goals. If you have any questions or need further information, please reach out to us at Bayview Pharmacy. This gel is used for delivering medication or providing lubrication and therapeutic effects for various gynecological purposes. Accurately weigh and/or measure each ingredient. Thoroughly pulverize the required number of sildenafil tablets for the prescription.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Viagra Generic | 150mg | 10 Pills | 36.73€ 34.98€ | |
| Kamagra Oral Jelly | 100mg | 110 + 9 Sachets | 334.87€ 318.92€ | |
| Viagra Generic | 150mg | 270 + 10 Pills | 326.61€ 311.06€ | |
| Kamagra Polo | 100mg | 272 + 12 Pills | 622.94€ 593.28€ | |
| Kamagra Polo | 100mg | 84 + 4 Pills | 244.49€ 232.85€ | |
| Viagra Generic | 25mg | 90 + 6 Pills | 105.03€ 100.03€ | |
| Viagra Generic | 200mg | 20 Pills | 61.69€ 58.75€ | |
| Viagra Generic | 100mg | 20 Pills | 45.58€ 43.41€ | |
| Kamagra | 100mg | 84 + 6 Pills | 264.44€ 251.85€ | |
| Viagra Generic | 150mg | 60 + 4 Pills | 111.25€ 105.95€ |
(A high-speed mill/coffee grinder works well.) Add the propylene glycol and purified water to the sildenafil citrate powder, and form a smooth paste.
Uses of Vega Oral Jelly
It is crucial to discuss all current medications, including over-the-counter drugs and supplements, with a healthcare provider to ensure compatibility and safety. If you have any questions or concerns about potential drug interactions with Sildenafil Citrate 10 mg/g Vaginal Gel, please reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to assist you with any inquiries and provide guidance for the safe use of this formulation. Sildenafil Citrate 10 mg/g Vaginal Gel is a specialized formulation designed to deliver sildenafil citrate directly to the vaginal tissue. This gel-like semisolid formulation is dispensed in a tube, allowing for easy and controlled application.
2.9. Ex Vivo Skin Permeation Studies
The primary mechanism of action of sildenafil citrate involves the inhibition of phosphodiesterase type 5 (PDE5), an enzyme that breaks down cyclic guanosine monophosphate (cGMP). By inhibiting PDE5, sildenafil citrate increases the levels of cGMP, leading to the relaxation of smooth muscle and vasodilation. This process enhances blood flow to the targeted area, which can be beneficial for various gynecological conditions. In the context of vaginal application, the increased blood flow can help address conditions such as female sexual arousal disorder (FSAD) by improving genital blood flow, potentially enhancing sexual arousal and response. Additionally, the gel formulation provides a lubricating effect, which can alleviate discomfort during intercourse, particularly in individuals experiencing vaginal dryness or atrophy.
3.5. In Vitro Drug Release
The localized application ensures that the medication acts directly where it is needed, minimizing systemic absorption and reducing the risk of systemic side effects. For prescribers, it is important to consider the patient's overall health status and any contraindications associated with sildenafil citrate, such as concurrent use of nitrates or certain cardiovascular conditions. The 10 mg/g concentration allows for precise dosing, and the gel form ensures that the medication is evenly distributed across the vaginal mucosa. This formulation can be particularly useful for patients who may not tolerate oral sildenafil due to gastrointestinal side effects or those who require localized treatment for specific gynecological issues. Patients using Sildenafil Citrate 10 mg/g Vaginal Gel should follow the application instructions provided by their healthcare provider to ensure optimal results. Incorporate into sufficient hydrophilic ointment (Dermabase, Vanicream) to final weight and mix well. Warm the purified water to about 70°C and add to the powder-propylene glycol mixture.
Uses / Indications
It is specifically formulated for easy and controlled application in the vaginal area. The gel should be applied as directed by your healthcare provider. Typically, it is dispensed from a tube and applied directly to the vaginal area for optimal therapeutic effects. You should consult your healthcare provider before using this gel if you are pregnant or breastfeeding to ensure it is safe for you and your baby. Some users may experience mild irritation or discomfort.
3.1. Fabrication of Sildenafil-Loaded Bilosomes (SDF-BS)
If you experience severe side effects or an allergic reaction, discontinue use and consult your healthcare provider immediately. The frequency of use should be determined by your healthcare provider based on your specific needs and condition. Before using this gel with other vaginal products, consult your healthcare provider to avoid potential interactions or reduced effectiveness. Store the gel at room temperature, away from direct sunlight and moisture. Keep it out of reach of children and pets.
Are you currently using Sildenafil (Viagra, Revatio)?
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue sildenafil 100mg hexal with your regular schedule. Yes, a prescription is typically required for this medication. Consult your healthcare provider to determine if it is appropriate for you. This gel is specifically formulated for vaginal use and is not intended for use by men. Package in tight, light-resistant containers.1 A beyond-use date of 14 days can be used for this preparation when stored in a refrigerator.1 Sildenafil cream and sildenafil gel have been used to improve uterine artery flow and endometrial development in patients undergoing in vitro fertilization. Study design:~This is a prospective self-controlled clinical trial.~Study subjects:~Investigators counseled and recruited 42 infertile women who had been diagnosed with anovulatory infertility, with normal baseline FSH, LH, and free testosterone levels, patent tubes on hysterosalpingography, and normal male semen analysis.~By the time they were enrolled in the study, all women had already completed 5 ovulatory cycles of Clomiphene citrate induction (in a dose of 100 mg/ day in two divided doses starting from day 3 of the cycle for 5 days) but without conception (clomiphene citrate failure) with thin endometrium (\<8mm) in at least 3 cycles.
- Sildenafil gel is sometimes combined with other topical vasodilators to enhance effect.
- The onset of action generally occurs within 15-30 minutes after application.
- Duration of sildenafil gel effects typically lasts 1-2 hours.
- Side effects can include local burning, redness, or itching at the application site.
- It should not be applied to broken or irritated skin to avoid complications.
- Using sildenafil gel does not protect against sexually transmitted infections.
- Patients should inform healthcare providers of all medications before using sildenafil gel.
Ovulation was documented sonographically, and with day-21 serum progesterone exceeding 5 ng/ ml in all cases.~Exclusion criteria:~Women with major medical problems, male factor infertility, endocrine abnormalities such as hyperprolactinemia or abnormal thyroid functions, prior ovarian or adnexal surgery, or organic pelvic pathology were not included in the study.~Intervention:~Sixth cycle (Clomiphene citrate only):~Enrolled cases were asked to continue with Clomiphene citrate induction ( at the same dose) for the 6th cycle. A gel base, without medicament (vehicle only), was applied vaginally in a dose of 5 gm twice per day, from cycle day 8 to the day of HCG administration ( when follicular diameter reached 18 mm). Endometrial thickness and Uterine artery Doppler assessment were done in the late proliferative phase ( Day of HCG injection).~Seventh cycle ( Sildenafil vaginal gel and Clomiphene cycle):~Those who didn't conceive on the sixth cycle (41 women) were asked to have an extra (7th) cycle in which they were prescribed the usual dose of Clomiphene citrate in addition to sildenafil vaginal gel.
- Some clinical studies suggest sildenafil gel causes less headache than oral forms.
- Topical application reduces systemic blood concentrations, minimizing cardiovascular risks.
- The gel form is especially suitable for patients with gastrointestinal issues.
- Use with caution in patients with certain dermatological diseases.
- Consult a physician before switching from oral to topical sildenafil formulations.
- Regular follow-ups help adjust dosage and monitor effectiveness.
- Use in women is not well studied and generally not recommended.
The dose was 5 g gel containing 50 mg sildenafil, applied vaginally twice daily from cycle day 8 to Day of HCG injection.
| Drug Class | Examples | Effect | Recommendation |
|---|---|---|---|
| Nitroglycerin | Nitroglycerin | Severe hypotension | Avoid concomitant use |
| Alpha-blockers | Doxazosin, Tamsulosin | Enhanced blood pressure lowering | Use with caution |
| CYP3A4 inhibitors | Ketoconazole, Erythromycin | Increased sildenafil plasma levels | Dose adjustment may be necessary |
| Other PDE5 inhibitors | Tadalafil, Vardenafil | Additive effect and increased risk of side effects | Avoid combining |
The gel was prepared in collaboration with the department of pharmaceutics, faculty of Pharmacy, Assiut University.
| Step | Procedure | Tips | Precautions |
|---|---|---|---|
| 1 | Clean and dry the application area | Use alcohol wipes for cleanliness | Avoid open wounds |
| 2 | Apply a small amount (about 0.5 g) evenly | Use applicator if provided | Do not overdose |
| 3 | Allow absorption for 10-15 minutes | Do not massage vigorously | Avoid bathing immediately after |
| 4 | Wash hands thoroughly afterward | Prevent inadvertent transfer to other areas | Keep out of reach of children |
Sixty grams of gel were prepared in tubes and every patient was given 10 applicators like that used for administration of vaginal antimycotic creams to use them for applying the gel.~Evaluation of the study end points:~On day of HCG injection (main follicular diameter of 18 mm) in the 6th, and 7th cycles, women came for follow up and had transvaginal sonographic assessment of their endometrial thickness.
When Not to Use
Consult a healthcare provider for appropriate treatments for male conditions. Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.No compounded medications are reviewed by the FDA for safety or efficacy. No compounded medications are reviewed by the FDA for safety or efficacy.