^ "Counterfeit Viagra Pills, Footwear, Belts, Car Emblems and Headphones Worth over $32 Million Seized at the LA/Long Beach Seaport U.S. Customs and Border Protection". Archived from the original on 12 October 2013. "Yes, There Is a Way to Get Generic Viagra". Archived from the original on 2 May 2016. "Pfizer Wins Viagra Patent Infringement Case Against Teva Pharmaceuticals". Archived from the original on 11 January 2015. ^ "Pfizer Completes Transaction to Combine Its Upjohn Business with Mylan". Retrieved 17 June 2024 – via Business Wire.

6.1 Clinical Trials Experience

Archived from the original on 26 September 2008. Our clinicians regularly offer patients the opportunity to take part in trials of new drugs and treatments. Morriston Hospital in Swansea, was the first in the world to trial Viagra! ^ Boolell M, Allen MJ, Ballard SA, Gepi-Attee S, Muirhead GJ, Naylor AM, et al. "Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction".

How does sildenafil work (mechanism of action)?

"Sildenafil (Viagra), a potent and selective inhibitor of Type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction". "Drug repositioning: identifying and developing new uses for existing drugs". Archived from the original on 22 April 2019. Archived from the original on 10 June 2019. "Health situation in former communist bloc is dire, says Unicef". Archived from the original on 17 June 2024.

Product	Dosage	Quantity + Bonus	Price
Kamagra Polo	100mg	84 + 4 Pills	244.49€ 232.85€
Kamagra Polo	100mg	272 + 12 Pills	622.94€ 593.28€
Kamagra Soft Tabs	100mg	180 + 8 Pills	425.45€ 405.19€
Viagra Generic	50mg	20 Pills	40.52€ 38.59€
Kamagra Polo	100mg	180 + 8 Pills	446.52€ 425.26€
Viagra Generic	150mg	120 + 8 Pills	177.58€ 169.12€
Kamagra Oral Jelly	100mg	90 + 8 Sachets	303.56€ 289.10€
Kamagra Soft Tabs	100mg	120 + 6 Pills	311.78€ 296.93€
Kamagra Soft Tabs	100mg	84 + 4 Pills	233.05€ 221.95€
Kamagra	100mg	84 + 6 Pills	264.44€ 251.85€
Viagra Generic	25mg	120 + 6 Pills	125.56€ 119.58€
Viagra Generic	150mg	180 + 10 Pills	236.46€ 225.20€
Kamagra Oral Jelly	100mg	10 Sachets	54.55€ 51.95€
Kamagra Polo	100mg	120 + 6 Pills	327.15€ 311.57€

"Viagra patent expires in June, says Brazilian court". Archived from the original on 17 April 2012. ^ "Revatio patent ruled invalid for lack of sound prediction and obviousness". Archived from the original on 3 March 2016.

Warnings & Precautions

^ "Viagra to go generic in 2017 according to Pfizer agreement". Archived from the original on 1 December 2017. "Sex, Drugs and That Little Blue Pill". Archived from the original on 6 December 2017. "Why Pfizer Is About to Slash Viagra's Price in Half".

13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility

Archived from the original on 7 December 2017. "Pfizer to lose patent of drug Viagra, Indian companies gear up with copycat versions: Pfizer's patent for the formulation of Viagra, used to treat impotence in men, ends in the US in 2020". Archived from the original on 17 April 2021. ^ "Set to conquer US, Indian 'Viagras' may give Pfizer a hard Time". Archived from the original on 22 December 2020. {{cite web}}: CS1 maint: deprecated archival service (link) ^ Teva Canada Ltd. v. Pfizer Canada Inc., 2012 SCC 60 at par. "Supreme Court ruling could lead to cheaper versions of Viagra". Archived from the original on 10 March 2013.

Side Effects

^ "Pfizer Courting More Controversy with Viagra 'Advergaming'". Archived from the original on 19 December 2019. Archived from the original on 6 May 2018. Archived from the original on 9 January 2009. Archived from the original on 22 February 2021.

Limitation of Warranty & Liability

^ a b "Viagra now available over the counter without prescription in the UK". Archived from the original on 26 March 2021. Archived from the original on 8 December 2013. "The coming generics threat to Pfizer's Viagra brand just got scarier". Archived from the original on 9 September 2017. "Canadian Supreme court rules Viagra sildenafil chewable tablets patent invalid". Archived from the original on 11 November 2012.

Parameter	Value	Description	Remarks
Absorption	Rapid, within 30-60 min	Time to peak plasma concentration	最佳服用时间为餐前或空腹
Bioavailability	Approx. 40%	Percentage of dose reaching systemic circulation	影响药效强度
Half-life	4 hours	Time taken to reduce plasma concentration by half	影响药物持续时间
Metabolism	Hepatic (mainly CYP3A4)	Liver enzymes metabolize sildenafil	酒精或药物相互作用可能影响代谢

^ "Viagra patent tossed out by Supreme Court: Decision allows generic versions of drug to be produced". Archived from the original on 18 September 2013. ^ "Pfizer Canada drops Viagra price after generic versions get Supreme Court green light". Archived from the original on 30 November 2012. Archived from the original on 27 December 2013. "In rare move, Pfizer asks Supreme Court to reconsider ruling that killed Viagra patent".

INDICATIONS AND USAGE

"Online pharmacies suspected of counterfeit drug sales". ^ "Erectile Dysfunction Medication the Most Seized Drug During Global Crackdown, Interpol Says". ^ "Global illicit medicines targeted by INTERPOL operation". Archived from the original on 10 December 2023. ^ "Israeli-made AI exposes international fake Viagra network". Archived from the original on 5 February 2013. "The Supreme Court of Canada holds Pfizer's Viagra patent invalid". Archived from the original on 20 May 2013. ^ "Actavis Launches Generic Viagra in Europe as Patents Expire". Archived from the original on 29 October 2013. "What Will Happen When Viagra Goes Generic?". Archived from the original on 23 April 2011. ^ "Is Viagra about to lose its pulling power in the UK?". Archived from the original on 30 October 2013.

2 DOSAGE AND ADMINISTRATION

Archived from the original on 1 November 2012. ^ Gurevich M, Cormier N, Leedham U, Brown-Bowers A (August 2018). Sexuopharmaceutical use by men as prevention and proficiency". "Spreading the Word, but What Word is That? Viagra and Male Sexuality in Popular Culture".

Does sildenafil interact with other medicines (drug interactions)?

"A new view of women's sexual problems: Why new? Archived from the original on 3 January 2009. Archived from the original on 12 October 2008. "Sales of Impotence Drugs Fall, Defying Expectations". Archived from the original on 11 October 2007. Archived from the original on 22 August 2009. Archived from the original on 25 June 2007. "Viagra from the pharmacist: insight from reclassification in New Zealand". Archived from the original on 17 May 2021. ^ "Generic Viagra developers queue up, but may have to wait". Archived from the original on 28 December 2021. ^ "Approved Viagra copies flood drugstores in Korea". ^ "Viagra prescriptions almost triple in a decade". Archived from the original on 1 July 2024. ^ "MHRA reclassifies Viagra Connect tablets to a Pharmacy medicine". ^ "Viagra to be available without prescription in UK". Sildenafil is used to treat erectile dysfunction (also called sexual impotence). Sildenafil belongs to a group of medicines called phosphodiesterase 5 (PDE5) inhibitors. These medicines prevent an enzyme called phosphodiesterase type-5 from working too quickly. The penis is one of the areas where this enzyme works. Erectile dysfunction is a condition where the penis does not harden and expand when a man is sexually excited, or when he cannot keep an erection.

17. Patient Counseling Information

^ a b "Pfizer Settles Viagra® Patent Litigation With Teva". "Lockout Supplements Issues Voluntary Nationwide Recall of Boner Bears Chocolate Syrup Due to Undeclared Sildenafil". Archived from the original on 19 November 2016. "Counterfeit Viagra, Cialis, Levitra: The Ultimate Guide". Archived from the original on 10 January 2017. When a man is sexually stimulated, his body's normal response is to increase blood flow to his penis to produce an erection. By controlling the enzyme, sildenafil helps to maintain an erection after the penis is stroked.

Precaution/Contraindication	Details	Advice
Nitrate use	Contraindicated with sildenafil	Risk of severe hypotension
Cardiovascular disease risk	Use with caution	Consult cardiologist before use
Liver or kidney impairment	Dose adjustment needed	Monitor liver/kidney function tests
Allergies to sildenafil or excipients	Check ingredients before administration	Discontinue if allergic reactions occur

Without physical action to the penis, such as that occurring during sexual intercourse, sildenafil will not work to cause an erection. Sildenafil is also used in both men and women to treat the symptoms of pulmonary arterial hypertension. This is a type of high blood pressure that occurs between the heart and the lungs. When hypertension occurs in the lungs, the heart must work harder to pump enough blood through the lungs. Sildenafil works on the PDE5 enzyme in the lungs to relax the blood vessels. This will increase the supply of blood to the lungs and reduce the workload of the heart. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Appropriate studies have not been performed on the relationship of age to the effects of sildenafil in children younger than 1 year of age.

Sildenafil syrup is sometimes used in pediatric cases, off-label.
Off-label use in children requires careful dosage adjustment.
Lack of standardization makes typical dosing guidelines difficult.
Pharmacokinetics in syrup form are less well-studied.
Always seek professional medical advice before use.

Safety and efficacy have not been established. Sildenafil should never be used in children for erectile dysfunction. In general, sildenafil should not be used for pulmonary arterial hypertension in children, especially for chronic use. Use of sildenafil oral film is not indicated for use in the pediatric population. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of sildenafil in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving sildenafil.

Sildenafil syrup can cause side effects like headaches, flushing, or dizziness.
Combining sildenafil syrup with nitrates can be dangerous.
The syrup's consistency may vary; formulation stability is key.
Misuse or overdose can lead to serious cardiovascular issues.
Always consult a doctor before using sildenafil syrup.

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Ingredient	Quantity per 100ml	Function	备注
Sildenafil citrate	20 mg	Active pharmaceutical ingredient	主要成分，用于治疗勃起功能障碍
Xanthan gum	0.5 g	Thickening agent	用于增加粘稠度
Flavored syrup base	50 ml	Flavor enhancement	改善口感
Preservatives	As required	Prevent microbial growth	确保产品稳定性
Purified water	49.45 ml	Solvent	溶剂基础

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur.