All authors would like to thank the patients who participated in this study. No external funding was received for this study. The study was supported by departmental/investigator resources.
What is tadalafil and how does it work?
Clinical and preclinical treatment of urologic diseases with phosphodiesterase type 5 inhibitors: an update. Phosphodiesterase type 5 inhibitors for the treatment of female sexual dysfunction: a systematic review and meta-analysis. Ashton A, Weinstein W. Tadalafil reversal of sexual dysfunction caused by serotonin-enhancing medications in women. Tadalafil 5 mg daily treatment for sexual arousal disorder in type 1 diabetic premenopausal women. AM Rammah: Project development, Data Collection, Manuscript writing. SM Hassan and D Farouk: Clitoral Doppler assessment and data collection. All authors provided their agreement to publish this work. The Ethical Committee of the Urology department approved the research, as well as the Research Ethical Committee (REC) of the Faculty of Medicine, Cairo University (IRB number: N-436–2023, Approval date 10–12-2023).
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Cialis Generic | 20mg | 90 + 6 Pills | 154.71€ 147.34€ | |
| Cialis Generic | 2.5mg | 20 Pills | 40.73€ 38.79€ | |
| Cialis Generic | 20mg | 360 + 10 Pills | 427.34€ 406.99€ | |
| Cialis Generic | 60mg | 90 + 6 Pills | 196.67€ 187.30€ | |
| Cialis Generic | 20mg | 60 + 6 Pills | 117.76€ 112.15€ | |
| Cialis Generic | 2.5mg | 120 + 6 Pills | 128.93€ 122.79€ | |
| Cialis Generic | 2.5mg | 10 Pills | 28.51€ 27.15€ | |
| Cialis Generic | 2.5mg | 30 + 4 Pills | 51.95€ 49.48€ | |
| Cialis Generic | 60mg | 10 Pills | 41.22€ 39.26€ | |
| Cialis Generic | 60mg | 120 + 8 Pills | 240.18€ 228.74€ | |
| Cialis Generic | 60mg | 180 + 10 Pills | 313.11€ 298.20€ | |
| Cialis Generic | 20mg | 270 + 10 Pills | 335.21€ 319.25€ | |
| Cialis Generic | 20mg | 120 + 8 Pills | 188.15€ 179.19€ | |
| Cialis Generic | 60mg | 270 + 10 Pills | 443.96€ 422.82€ |
Clinical trial registration was done in February 2022 (ClinicalTrials.gov Identifier: NCT05266651). A written consent was obtained from each participant after a clear and a precise explanation of the study aim, methodology and risks.
| Drug/Substance | Interaction Type | Effect |
|---|---|---|
| Nitrates | Severe hypotension risk | Avoid concomitant use |
| CYP3A4 Inhibitors | Increased tadalafil levels | Dose adjustment needed |
| Alpha-blockers | Orthostatic hypotension | Monitor blood pressure |
| Grapefruit Juice | CYP3A4 inhibition | Potentially increased drug effect |
The authors declare no conflicts of interest. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Potential benefits for women
Female genital cutting is not a social coordination norm. In: Diagnostic and statistical manual of mental disorders. Washington, DC: American Psychiatric Association; 2000. p. 493–538.
Uncommon side effects
Female sexual dysfunction: classification, pathophysiology, and management. Washington DC: American Psychiatric Association; 2000. p. 493–538. Sexual function in women with female genital mutilation. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
More about tadalafil
It belongs to a class of drugs known as phosphodiesterase type 5 (PDE5) inhibitors, which work by relaxing your blood vessels and helping blood flow through the body more easily. They help treat erectile dysfunction by relaxing the blood vessels at the base of the penis during sexual stimulation, causing an erection Female sexual arousal disorder (FSAD) is defined as ‘reduced sensation, pleasure, or excitement during sexual activity’. [1] Due to the lack of research in this area, it’s not currently recommended for anyone with female sex organs to take tadalafil for sexual dysfunction, as it could have adverse effects. Aside from the unknown potential side effects, it may cause those currently seen in men, such as muscle aches, stuffy nose, digestive issues, along with other more serious conditions. You can learn more about the side effects of tadalafil here.
Cite this article
If you’re seeking support for sexual dysfunction, we highly recommend contacting your healthcare provider. Pulmonary hypertension (PH) is high blood pressure in the lungs, which makes it harder for the heart to pump blood around the body. If untreated, it could eventually cause heart failure. [2] Due to the seriousness of this condition, tadalafil can be prescribed to women with PH, and in some cases is even prescribed to women with PH during pregnancies. Tadalafil for female sexual function remains an understudied area, and until more research takes place, it’s not possible to safely prescribe this medication for intimate health concerns such as sexual dysfunction in women.
Pulmonary arterial hypertension
In summary, unless recommended by a licensed healthcare provider for a condition such as pulmonary hypertension, it’s not currently advised that women use tadalafil. To learn more about tadalafil and treatment options for erectile dysfunction, take a look at our blog here, or start a fast, free online consultation. Adebisi OY, Carlson K. Hypoactive Sexual Desire Disorder in Women [Internet]. Pregnancy, breastfeeding and fertility while taking tadalafil - Brand names: Cialis, Adcirca [Internet]. Can Low Dose Tadalafil Improve the Sexual Functions in Women with Genital Mutilation?.
| Use | Description | Evidence Level |
|---|---|---|
| Female Sexual Dysfunction | To improve libido and arousal | Experimental, some positive reports |
| Vestibular Disorders | To enhance blood flow in inner ear | Limited data |
| Pulmonary Hypertension | To reduce pulmonary artery pressure | Off-label, under clinical study |
Some benefits, especially in ability to achieve orgasm, were reported.
Cialis Safety for Women: Key Considerations
Female genital mutilation (FGM) is associated with female sexual dysfunction (FSD) through anatomical disruption and impaired genital vascular function. Phosphodiesterase-5 inhibition may enhance genital perfusion via nitric oxide–mediated pathways. We hypothesized that tadalafil improves sexual function and clitoral vascular parameters in women with FGM-related FSD. In this randomized, single-blind, placebo-controlled trial, 66 women with FGM-related FSD were randomized; 52 completed follow-up and were included in a modified intention-to-treat analysis (tadalafil 5 mg once daily, n = 25; placebo, n = 27) for 8 weeks. Sexual function was assessed using the Female Sexual Function Index (FSFI).
Study design
Their FGM type was classified on the basis of WHO criteria. Clitoral color Doppler ultrasonography measured peak systolic velocity (PSV), resistance index (RI), and pulsatility index (PI). The primary endpoint was the between-group difference in change in total FSFI score from baseline to 8 weeks. Tadalafil significantly improved total FSFI score compared with placebo (mean change +5.47 vs −0.41; p < 0.001). Improvements were observed across all FSFI domains except lubrication.
Safe dosages
Significant increases in clitoral PSV, RI, and PI were detected in the tadalafil group, whereas no significant changes occurred in the placebo group. Greater benefit was observed in women with type I FGM. Once-daily tadalafil 5 mg for 8 weeks significantly improves sexual function and genital vascular parameters in women with FGM-related FSD, supporting its potential therapeutic role in this population. The datasets generated and analyzed during the current study are available from the corresponding author on reasonable request. Diagnostic and Statistical Manual of Mental Disorders, 4th Ed Diagnostic and Statistical Manual of Mental Disorders, 4th Ed Basson R. Men and women who take selective or nonselective serotonin reuptake inhibitors (SRIs) commonly report sexual dysfunction; the main difficulties among women are orgasmic dysfunction and problems with arousal, including lubrication. Studies of selective phosphodiesterase type 5 inhibitors (sildenafil [Viagra], vardenafil [Levitra], and tadalafil [Cialis]) as therapy for cheap tadalafil women with sexual arousal disorder have produced mixed results. In this multisite trial, funded by sildenafil’s tadalafil 60mg uk manufacturer, researchers enrolled 98 women (mean age, 37) who had normal sexual function before treatment for depression, were being treated successfully with SRIs (usually fluoxetine, sertraline, or paroxetine; mean treatment time, 28 months), and had substantial s… Editorial BoardsContraception; Menopause; Contraceptive Technology Update; OBG Management; Medscape OB/GYN & Women’s Health Editorial BoardsContraception; Menopause; Contraceptive Technology Update; OBG Management; Medscape OB/GYN & Women’s Health Dr. Srishti Rastogi is a medical writer and healthcare professional dedicated to high-quality patient education and public health awareness. Leveraging her clinical background, she produces deeply researched, evidence-based content for digital health platforms and medical publications. Dr. Srishti’s unique dual perspective as a clinician and communicator allows her to craft content that builds trust and credibility with readers navigating sensitive health topics. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Unique Aspects of Clinical Trials in Male Sexual Dysfunction Generic name: tadalafil [ ta-DAL-a-fil ] Brand names: Adcirca, Cialis Drug classes: Agents for pulmonary hypertension, Impotence medications Tadalafil relaxes muscles of the blood vessels and increases blood flow to particular areas of the body. Tadalafil under the name of Cialis is used to treat erectile dysfunction (impotence) and symptoms of benign prostatic hypertrophy (enlarged prostate). Another brand of tadalafil is Adcirca, which is used to treat pulmonary arterial hypertension and improve exercise capacity in men and women.
Combining Therapies: Tadalafil, Oxytocin, and Bremelanotide (PT-141)
Women’s sexual dysfunction: revised and expanded definitions. Basson R. Women’s sexual dysfunction: revised tadalafil over the counter uk and expanded definitions. Epidemiology and risk factors of sexual dysfunction. The impact of female genital mutilation on sexual function: a study conducted in rural Sudan.
Tadalafil for pulmonary hypertension
Somalian women with female genital mutilation had increased risk of female sexual dysfunction: a cross-sectional observational study. Borghi C, Dell’Atti L. Tadalafil once daily: narrative review of a treatment option for female sexual dysfunctions in midlife and older women. The role of androgens in female sexual dysfunction. Female genital cutting: impact on women’s health.
Follow-up care
Sun X, Li C, Jin L, Fan Y, Wang D. Development and validation of Chinese version of the female sexual function index. Evaluation of genital self-image and sexual dysfunction in women with vulvar lichen planus or lichen sclerosus. Biostatistics 102: quantitative data—parametric and non-parametric tests. Efferson C, Vogt S, Elhadi A, Ahmed Hel F, Fehr E. Do not take tadalafil if you are also using a nitrate drug for chest pain or heart problems, including nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, and some recreational drugs such as "poppers".
- Tadalafil is being researched to treat female sexual desire disorder.
- It acts by increasing blood flow to genital tissues.
- Efficacy results are mixed and require further investigation.
- It is available under strict medical supervision in trials.
- Side effects in women include headaches and flushing.
- Some studies suggest benefits for postmenopausal women.
- It is not approved for general use in female sexual dysfunction.
- Women should always consult healthcare providers before trying.
- Its future depends on ongoing scientific validation.
Taking tadalafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure. Some medicines can cause unwanted or dangerous effects when used with tadalafil. Tell your doctor about all your current medicines, especially riociguat (Adempas). Contact your doctor or seek emergency medical attention if your erection is painful or lasts longer than 4 hours.
- Tadalafil is sometimes studied for female sexual arousal disorder.
- It may increase blood flow to genital areas in women.
- Tadalafil can help improve sexual satisfaction in women.
- Used off-label, as it’s not officially approved for women.
- Potential side effects include headache and flushing in women.
- Research on tadalafil’s effects on female libido is ongoing.
- Tadalafil might benefit women with sexual arousal issues.
- Dosage for women is not standardized; typically lower doses.
- Used in clinical trials to assess its safety for women.